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This the main problem regulates reward responses in acquiring food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both when they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to lose weight naturally can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight-loss and the people that go through it one should err to the side of caution and let the FDA do its job and demand some investigation be done so the public is aware of the side effects and dangers of the medications before we bring them. Keep in mind that drug companies have been in business to generate money and that they would say everything to keep people on their own medications. Researchers discovered that participants taking this drug for a year, lost weight within four weeks and have kept the weight off through the 56 weeks of the study. Contrave is a combination in the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which might be made up of several active ingredient, which may make them more efficient and safer. Combo-pilling could be the newest fad or in addition to this the newest to come under scrutiny and so it is just more publicly known although in the past, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills has become popular will be the fact that by right now there aren't any long term prescription diet pills that have been licensed by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and shouldn't be taken in people with seizure disorders. The drug can also raise blood pressure level and heart rate, and really should not be used in individuals with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise blood pressure level and heart rate and must not be used in patients with uncontrolled high blood pressure levels, as well as by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients using a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking. Please show your support by clicking the 'Like', 'Subscribe' and 'Share' buttons available on this page.