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Combo-pilling could be the newest fad or also the newest in the future under scrutiny and so it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular may be the fact that at the time of right now there are not any long term prescription diet pills that have been authorized by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be approved by the FDA. Seizures are a side effect with Contrave and mustn't be taken in those with seizure disorders. The drug could also raise blood pressure level and heartbeat, and shouldn't be used in individuals with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise blood pressure level and heartrate and must stop used in patients with uncontrolled high blood pressure level, along with by you are not heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients which has a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients towards the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation. "There were no warning signs of depression or suicidal thoughts in trial participants," said Fujioka.